Diabetes insípida central e hipotiroidismo secundario debidos a un macroadenoma hipofisario en un perro

Se expone el caso de una perra que presentaba inicialmente midriasis unilateral como único signo clínico. A los 12 meses apareció también midriasis en el otro ojo junto con poliuria, polidipsia, letargia y alopecia bilateral troncal. Tras distintas pruebas se diagnosticó diabetes insípida central e hipotiroidismo secundario, presuntamente debidos a un tumor hipofisario posteriormente confirmado mediante necropsia.

Time-optimal CNOT between indirectly coupled qubits in a linear Ising chain

We give analytical solutions for the time-optimal synthesis of entangling gates between indirectly coupled qubits 1 and 3 in a linear spin chain of three qubits subject to an Ising Hamiltonian interaction with equal coupling $J$ plus a local magnetic field acting on the intermediate qubit. The energy available is fixed, but we relax the standard assumption of instantaneous unitary operations acting on single qubits. The time required for performing an entangling gate which is equivalent, modulo local unitary operations, to the $\mathrm{CNOT}(1, 3)$ between the indirectly coupled qubits 1 and 3 is $T=\sqrt{3/2} J^{-1}$, i.e. faster than a previous estimate based on a similar Hamiltonian and the assumption of local unitaries with zero time cost. Furthermore, performing a simple Walsh-Hadamard rotation in the Hlibert space of qubit 3 shows that the time-optimal synthesis of the $\mathrm{CNOT}^{\pm}(1, 3)$ (which acts as the identity when the control qubit 1 is in the state $\ket{0}$, while if the control qubit is in the state $\ket{1}$ the target qubit 3 is flipped as $\ket{\pm}\rightarrow \ket{\mp}$) also requires the same time $T$.Comment: 9 pages; minor modification

Brachistochrone of Entanglement for Spin Chains

We analytically investigate the role of entanglement in time-optimal state evolution as an appli- cation of the quantum brachistochrone, a general method for obtaining the optimal time-dependent Hamiltonian for reaching a target quantum state. As a model, we treat two qubits indirectly cou- pled through an intermediate qubit that is directly controllable, which represents a typical situation in quantum information processing. We find the time-optimal unitary evolution law and quantify residual entanglement by the two-tangle between the indirectly coupled qubits, for all possible sets of initial pure quantum states of a tripartite system. The integrals of the motion of the brachistochrone are determined by fixing the minimal time at which the residual entanglement is maximized. Entan- glement plays a role for W and GHZ initial quantum states, and for the bi-separable initial state in which the indirectly coupled qubits have a nonzero value of the 2-tangle.Comment: 9 pages, 4 figure

Towards a better understanding of global land grabbing: an editorial introduction

ESR

El verderón serrano en invierno: patrones de distribución, el papel de los pinos e implicaciones para la conservación de la especie

The Citril finch Serinus citrinella is a Paleartic endemic species that breeds in the subalpine mountain zones of western temperate Europe. The species seems to be suffering a serious decline in its northern range, mainly in the Black Forest and the NE of the Alps. Numerous reasons have been provided for this decline, but all of them have been related to breeding habitats. Given that the species undergoes an altitudinal migration and that during winter it may use very different habitats, a sound knowledge of the distribution patterns and habitats used outside the breeding period is needed to conduct adequate conservation policies and management. This information, however, is largely lacking. The aim of this paper was to determine the current habitat used by Citril finches in north–eastern Spain during the winter, to analyse habitat suitability and to study movements, by investigating the origin of birds that overwinter in Catalonia. Citril finch distribution was modelled using both discriminant analysis and maximum entropy modelling, on the basis of species occurrences during winter in Catalonia (data from 1972–2009).El verderón serrano (Serinus citrinella) es una especie paleártica endémica que cría en zonas montañosas subalpinas de la Europa occidental templada. Esta especie parece que está sufriendo un gran declive en su área de distribución septentrional, principalmente en la Selva Negra y en el NE de los Alpes. Se han propuesto muchas razones para dicha disminución, pero todas ellas estaban relacionadas con los hábitats de cría. Dado que esta especie lleva a cabo una migración altitudinal, y que durante el invierno puede utilizar habitats muy distintos, se precisaría un buen conocimiento de los patrones de distribución y de los hábitats utilizados fuera del período reproductor, para poder establecer unas directrices de conservación y gestión adecuadas. Sin embargo, esta información es muy escasa. El propósito de este estudio es determinar el hábitat común utilizado por los verderones serranos en en nordeste de España durante el invierno, para analizar la idoneidad del habitat, y estudiar los movimientos, investigando el origen de la aves que invernan en Cataluña. La distribución se modelizó utilizando el análisis discriminante y la modelización de entropía máxima con los datos registrados desde 1972 al 2009 sobre la presencia de esta especie durante el invierno en Cataluña. Los resultados evidenciaron que la presencia de bosques abiertos mixtos de pino negral (Pinus nigra subsp. salzmanii) y pino silvestre o albar (Pinus sylvestris), con numerosas tierras de cultivo y plantas arvenses, en areas submediterráneas típicas en las que las temperaturas templadas de finales de invierno (días soleados) facilitan la apertura de las piñas, fueron las variables ecológicas y bioclimáticas claves responsables de la distribución del verderón serrano en invierno (valores AUC o área bajo la curva: datos de entrenamiento AUC = 0,955; datos del test AUC = 0,953). Analizamos las recuperaciones (N = 238) de 2.368 aves anilladas en las áreas de invernada y 12.648 aves anilladas en localizaciones subalpinas en los Pirineos adyacentes, desde 1977 al 2004. Los resultados de los datos de recuperación de anillas muestran que en el área de estudio se capturaron aves procedentes de muy diversas localizaciones dentro del área de distribución de la especie estudiada, incluyendo aves transpirenaicas procedentes de los Alpes. Ello enfatiza la gran movilidad de las poblaciones del verderón serrano hasta alcanzar las áreas de invernada. Desde el punto de vista de la conservación, la gran importancia de los pinos (principalmente del negral) para la distribución invernal de esta especie pone de manifiesto que cualquier amenaza para los pinos, especialmente los incendios forestales, tendrá grandes efectos adversos sobre las poblaciones del verderón serrano.This work was supported by grants from the Ministerio de Ciencia e Innovación (CGL 2009–10652)

Quality of care indicators for head and neck cancers : the experience of the European project RARECAREnet

Background: Monitoring and improving quality of cancer care has become pivotal today. This is especially relevant for head and neck cancers since the disease is complex, it needs multi therapy, patients tend to be older, they tend to have comorbidities and limited social support. However, information on quality of care for head and neck cancers is scarce. In the context of the project "Information Network on Rare Cancers" we aimed to identify indicators of quality of care specific for the head and neck cancers management and to measure the quality of care for head and neck cancers in different EU Member States. Methods: We defined indicators of quality of care for head and neck cancers based on a multidisciplinary and expert-based consensus process at a European level. To test the proposed indicators, we performed an observational population-based retrospective study in four countries (Ireland, Italy, Netherlands, and Slovenia) in the years 2009-2011. Results: The main quality indicators identified are: availability of formalized multidisciplinary team, participation in clinical and translational research; timeliness of care, high quality of surgery and radiotherapy, and of pathological reporting. For head and neck cancers, the quality of care did not reach the optimal standards in most of the countries analyzed. A high proportion of patients was diagnosed at an advanced disease stage, showed delays in starting treatment (especially for radiotherapy), and there was only a very limited use of multi therapy. Conclusions: According to the achieved consensus, indicators of quality of care for head and neck cancers have to cover the patient journey (i.e., diagnosis and treatment). Our results, showed suboptimal quality of care across countries and call for solutions for ensuring good quality of care for head and neck cancer patients in all EU countries. One possible option might be to refer head and neck cancer patients to specialized centers or to networks including specialized centers

Environmental Costs of Government-Sponsored Agrarian Settlements in Brazilian Amazonia

Brazil has presided over the most comprehensive agrarian reform frontier colonization program on Earth, in which ~1.2 million settlers have been translocated by successive governments since the 1970's, mostly into forested hinterlands of Brazilian Amazonia. These settlements encompass 5.3% of this ~5 million km2 region, but have contributed with 13.5% of all land conversion into agropastoral land uses. The Brazilian Federal Agrarian Agency (INCRA) has repeatedly claimed that deforestation in these areas largely predates the sanctioned arrival of new settlers. Here, we quantify rates of natural vegetation conversion across 1911 agrarian settlements allocated to 568 Amazonian counties and compare fire incidence and deforestation rates before and after the official occupation of settlements by migrant farmers. The timing and spatial distribution of deforestation and fires in our analysis provides irrefutable chronological and spatially explicit evidence of agropastoral conversion both inside and immediately outside agrarian settlements over the last decade. Deforestation rates are strongly related to local human population density and road access to regional markets. Agrarian settlements consistently accelerated rates of deforestation and fires, compared to neighboring areas outside settlements, but within the same counties. Relocated smallholders allocated to forest areas undoubtedly operate as pivotal agents of deforestation, and most of the forest clearance occurs in the aftermath of government-induced migration

Double Diffraction Dissociation at the Fermilab Tevatron Collider

We present results from a measurement of double diffraction dissociation in $\bar pp$ collisions at the Fermilab Tevatron collider. The production cross section for events with a central pseudorapidity gap of width $\Delta\eta^0>3$ (overlapping $\eta=0$) is found to be $4.43\pm 0.02{(stat)}{\pm 1.18}{(syst) mb}$ [$3.42\pm 0.01{(stat)}{\pm 1.09}{(syst) mb}$] at $\sqrt{s}=1800$ [630] GeV. Our results are compared with previous measurements and with predictions based on Regge theory and factorization.Comment: 10 pages, 4 figures, using RevTeX. Submitted to Physical Review Letter

Measurement of neutral current e+/-p cross sections at high Bjorken x with the ZEUS detector

The neutral current e+/-p cross section has been measured up to values of Bjorken x of approximately 1 with the ZEUS detector at HERA using an integrated luminosity of 187 inv. pb of e-p and 142 inv. pb of e+p collisions at sqrt(s) = 318GeV. Differential cross sections in x and Q2, the exchanged boson virtuality, are presented for Q2 geq 725GeV2. An improved reconstruction method and greatly increased amount of data allows a finer binning in the high-x region of the neutral current cross section and leads to a measurement with much improved precision compared to a similar earlier analysis. The measurements are compared to Standard Model expectations based on a variety of recent parton distribution functions.Comment: 39 pages, 9 figure